Table 4.
Number and percentage of the most-prescribed drugs (ATC chemical level) by gestational age in 2014.
| Very Preterm Neonates | Preterm Neonates | Term Neonates | Total | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GA 24–27 Weeks | GA 28–30 Weeks | GA 31–33 Weeks | GA 34–36 Weeks | GA ≥ 37 Weeks | |||||||||||||
| N = 15 | n | % | N = 22 | n | % | N = 34 | n | % | N = 59 | n | % | N = 74 | n | % | N = 204 | n | % |
| Caffeine | 15 | 100 | Caffeine | 22 | 100 | Tobramycin | 34 | 100 | Phytomenadione | 56 | 94.9 | Phytomenadione | 66 | 89.2 | Phytomenadione | 186 | 91.2 |
| Cholecalciferol | 14 | 93.3 | Cholecalciferol | 22 | 100 | Piperacillin | 34 | 100 | Tobramycin | 50 | 84.7 | Tobramycin | 60 | 81.1 | Tobramycin | 178 | 87.3 |
| Midazolam | 13 | 86.7 | Tobramycin | 21 | 95.5 | Phytomenadione | 33 | 97.1 | Piperacillin | 50 | 84.7 | Piperacillin | 60 | 81.1 | Piperacillin | 177 | 86.8 |
| Piritramide | 13 | 86.7 | Piperacillin | 21 | 95.5 | Caffeine | 32 | 94.1 | Theophylline | 19 | 32.2 | Midazolam | 31 | 41.9 | Caffeine | 89 | 43.6 |
| Tobramycin | 13 | 86.7 | Phytomenadione | 21 | 95.5 | Cholecalciferol | 17 | 50.0 | Midazolam | 19 | 32.2 | Phenobarbital | 26 | 35.1 | Midazolam | 87 | 42.6 |
| Piperacillin | 12 | 80.0 | Ferrous glycine sulfate | 17 | 77.3 | Theophylline | 13 | 38.2 | Phenobarbital | 19 | 32.2 | Piritramide | 25 | 33.8 | Phenobarbital | 80 | 39.2 |
| Fentanyl | 11 | 73.3 | Phenobarbital | 15 | 68.2 | Midazolam | 12 | 35.3 | Fentanyl | 19 | 32.2 | Metamizole sodium | 23 | 31.1 | Fentanyl | 73 | 35.8 |
| Furosemide | 10 | 66.7 | Piritramide | 13 | 59.1 | Phenobarbital | 10 | 29.4 | Caffeine | 18 | 30.5 | Fentanyl | 22 | 29.7 | Piritramide | 70 | 34.3 |
| Phenobarbital | 10 | 66.7 | Tropicamide | 13 | 59.1 | Fentanyl | 10 | 29.4 | Vecuronium | 14 | 23.7 | Furosemide | 21 | 28.4 | Cholecalciferol | 65 | 31.9 |
| Phytomenadione | 10 | 66.7 | Midazolam | 12 | 54.5 | Vecuronium | 10 | 29.4 | Furosemide | 13 | 22.0 | Sodium fluoride, Combinations | 17 | 23.0 | Theophylline | 63 | 30.9 |
| Vecuronium | 10 | 66.7 | Dobutamine | 12 | 54.5 | Metamizole sodium | 10 | 29.4 | Metamizole sodium | 12 | 20.3 | Theophylline | 16 | 21.6 | Metamizole sodium | 60 | 29.4 |
| Ferrous glycine sulfate | 9 | 60.0 | Hydrochloro-thiazide | 12 | 54.5 | Ferrous glycine sulfate | 9 | 26.5 | Sodium fluoride, Combinations | 11 | 18.6 | Omeprazole | 16 | 21.6 | Furosemide | 60 | 29.4 |
| Ibuprofen | 9 | 60.0 | Spironolactone | 12 | 54.5 | Piritramide | 9 | 26.5 | Piritramide | 10 | 16.9 | Epinephrine | 15 | 20.3 | Vecuronium | 58 | 28.4 |
| Vancomycin | 9 | 60.0 | Fentanyl | 11 | 50.0 | Tropicamide | 9 | 26.5 | Dobutamine | 9 | 15.3 | Vecuronium | 14 | 18.9 | Dobutamine | 44 | 21.6 |
| Dobutamine | 8 | 53.3 | Natural phospholipids | 11 | 50.0 | Natural phospholipids | 8 | 23.5 | Norepinephrine | 9 | 15.3 | Norepinephrine | 13 | 17.6 | Ferrous glycine sulfate | 44 | 21.6 |
| Hydrochloro-thiazide | 8 | 53.3 | Furosemide | 10 | 45.5 | Metronidazole | 7 | 20.6 | Omeprazole | 8 | 13.6 | Vancomycin | 12 | 16.2 | Vancomycin | 43 | 21.1 |
| Spironolactone | 8 | 53.3 | Vecuronium | 10 | 45.5 | Dobutamine | 6 | 17.6 | Cholecalciferol | 7 | 11.9 | Chloral hydrate | 12 | 16.2 | Epinephrine | 40 | 19.6 |
| Tropicamide | 8 | 53.3 | Vancomycin | 9 | 40.9 | Hydrochloro-thiazide | 6 | 17.6 | Natural phospholipids | 7 | 11.9 | Oxymetazoline | 12 | 16.2 | Norepinephrine | 37 | 18.1 |
| Diazepam | 7 | 46.7 | Palivizumab | 9 | 40.9 | Spironolactone | 6 | 17.6 | Metronidazole | 7 | 11.9 | Metronidazole | 11 | 14.9 | Metronidazole | 37 | 18.1 |
| Epinephrine | 7 | 46.7 | Epinephrine | 8 | 36.4 | Furosemide | 6 | 17.6 | Vancomycin | 7 | 11.9 | Esketamine | 11 | 14.9 | Tropicamide | 37 | 18.1 |
| Meropenem | 7 | 46.7 | Meropenem | 8 | 36.4 | Vancomycin | 6 | 17.6 | Potassium canrenoate | 7 | 11.9 | Heparin | 11 | 14.9 | Spironolactone | 36 | 17.6 |
N: number of patients in age group; n: number of patients exposed to a drug; %: exposure rate to a drug in that age group.