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. 2020 Oct 14;8(2):e001188. doi: 10.1136/jitc-2020-001188

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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Immunohistochemistry and histology of tertiary lymphoid structures (TLS). (A–H) Cellular composition of TLS. (A) CD4⁺ T cells. (B) CD8⁺ T cells. (C) CD20⁺ B cells. (D) CD11c⁺ dendritic cells. (E) CD45RO⁺ memory T cells. (F) anti-NCR1⁺ natural killer cells. (G) FOXP3⁺ regulatory T cells. (H) CD68⁺ tumor-associated macrophages. Magnification: 100×. (I–K) TLS stained with H&E. The presence of TLS in NF-PanNETs (I), functional PanNETs (J), and PanNECs (K). Top row, magnification: 100×. Bottom row, magnification: 400×. NF-PanNETs, non-functional PanNETs; PanNECs, pancreatic neuroendocrine carcinomas; PanNETs, pancreatic neuroendocrine tumors.