Table 3.
Sequence of cell-penetrating peptides (CPPs) for nucleic acid delivery.
| CPPs | Sequences | Cargos |
|---|---|---|
| GALA | WEAALAEALAEALAEHLAEALAEALEALAA | DNA [58] |
| KALA | WEAKLAKALAKALAKHLAKALAKALKACEA | DNA [58] |
| RALA | WEARLARALARALARHLARALARALRACEA | DNA [58,59], siRNA [60], mRNA [61] |
| RAWA | RAWARALARALRALARALRALAR | DNA [70] |
| PepFect3 | Stearyl-AGYLLGKINLKALAALAKKIL-NH2 | SCOs [62], pDNA [63]. |
| PepFect6 | Stearyl-AGYLLK(K(K2(tfq4)))INLKALAALAKKIL-NH2 | siRNA [64] |
| PepFect14 | Stearyl-AGYLLGKLLOOLAAAALOOLL-NH2 | SCOs [71], pDNA [65], siRNA [72] |
| NickFect1 | Stearyl-AGY(PO3)LLKTNLKALAALAKKIL-NH2 | SCOs [66], pDNA [63] |
| NickFect51 | (Stearyl-AGYLLG)-δ-OINLKALAALAKKIL-NH2 | SCOs, pDNA, siRNA [67,68] |
| NickFect55 | (Stearyl-AGYLLG)-δ-OINLKALAALAKAIL-NH2 | pDNA [69]. |
(K(K2(tfq4))) is a tetra(trifluoromethylquinoline) derivate.