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. 2020 Sep 16;9(9):753. doi: 10.3390/pathogens9090753

Figure 1.

Figure 1

Distinct patterns of gut microbiome diversity in mouse models of transient receptor potential (TRP)A1 knockout, TRPV1 knockout and TRPA1V1 double-knockout as compared to each other as well as to the TRP wild-type counterparts. (a) Beta-diversity (PCoA) plot of the gut microbiome in mouse models of TRPA1 knockout (A1KO), TRPV1 knockout (V1KO) and TRPA1V1 double-knockout (A1V1dKO) versus TRP wild-type (TRP-WT) counterparts. (b–e) Alpha-diversity indices i.e., PD whole tree (phylogenetic diversity), Observed number of operational taxonomic units (OTUs), Chao1 (species richness) and Shannon (species evenness) in mouse models of TRPA1 knockout (A1KO), TRPV1 knockout (V1KO) and TRPA1V1 double-knockout (A1V1dKO) versus TRP wild-type (TRP-WT) counterparts. § Kruskal–Wallis test; * p < 0.05, ** p < 0.001 (pair-wise Dunn’s post-hoc test).