Table 1.
Published articles by name and reference with associated data.
| Author [ref] |
Type of Study Pre- or Post-Treatment | Test T/Control C Group Treatment Tx Delivered (χ = Unknown Value) |
Light Therapy Parameters (χ = Unknown Value) |
Outcome VAS/S (sig.) (χ = Un-Known Value) |
Comments RT = Radiotherapy CT = Chemotherapy |
|---|---|---|---|---|---|
| Barasch, 1995 [25] |
RCT DB Post-treatment |
20 Patients. Split mouth. Tx delivered 1 x day x 5 days. 5 sites @ χ points. |
λ632.8, CW, near-contact, 25 mW, fluence 1.0 J/cm2, Irrad. 0.04 W/cm2, total energy 28 J, Beam dia 10 mm, 0.8 cm2, 40 s |
1/2 | RT + CT Area treated 28 cm2 |
| Cowen, 1997 [26] |
RCT DB Pre-treatment |
30 Patients. T—15, C—15. Tx delivered 1 x day x 5 days. 5 sites @15 points. | λ632.8, CW, Spot 1 cm, 60 mW, fluence 1.5 J/cm2, Irrad 0.06 W/cm2, total energy 45 J, Beam dia 1.2 mm, 1.0 cm2, 10 s/point | 1/3 | RT + CT Area treated 75 cm2 |
| Bensadoun, 1999 [27] |
RCT DB Pre-treatment |
30 Patients. T—15, C—15. Tx delivered 1 x day x 35 days. χ sites @9 points. | λ632.8, CW, Spot 1 cm, 60 mW, fluence 2 J/cm2, Irrad 0.06 W/cm2, total energy 17.8 J, Beam dia 1.2 mm, 1.0 cm2 33 s/point | 1/3 | RT Area treated 9 cm2 |
| Antunes, 2007 [28] |
RCT B Pre-treatment |
38 Patients. T—19, C—19. Tx delivered 1 x day x χ days. 9 sites @135 points. | λ660, CW, Spot 1 cm, 46.7 mW, fluence 8.9 J/cm2, Irrad 0.0042 W/cm2, total energy 33.75 J, Beam dia 1.6mm, 0.028 cm2, 16.7 s/point | 1/3 | CT |
| Arun, 2006 [29] |
RCT DB Pre-treatment |
50 Patients. T—25, C—25. Tx delivered 1 x day x 5 days. 3 sites @ χ points. | λ632.8, CW, 10 mW, fluence 1.8 J/cm2, Irrad. χ W/cm2, total energy 5.4 J, Beam dia χ, χ cm2, 180 s | 2/3 | RT |
| Schubert, 2007 [30] |
RCT DB Pre-treatment |
70 Patients. T(i)—23, T(ii) 23 C—24. Tx delivered 1 x day x 10 days. 6 sites @ χ points. | T(i) λ660, CW, Spot 1 cm, 40 mW, fluence 71 J/cm2, Irrad. 0.04 W/cm2, total energy χ J, Beam dia 1.6 mm, 0.028 cm2, 50 s T(ii) λ780, CW, Spot 1 cm, near-contact, 60 mW, fluence 107.1 J/cm2, Irrad. 0.06 W/cm2, total energy 28 J, Beam dia 1.6 mm, 0.028 cm2, 33 s |
2/2 | CT CT + RT 660 > 780 |
| Abramoff, 2008 [31] |
RCT B Pre-treatment |
14 Patients. T—7, C—7. Tx delivered 0.5 x day x 44 days. 7 sites @ 126 points. | λ685, CW, in contact, 35 mW, fluence 72 J/cm2, Irrad 11.67 W/cm2, total energy χ J, Beam dia 0.6 mm, 0.003 cm2, 54 s | 1/3 | CT |
| Kuhn, 2009 [32] |
RCT DB Post-treatment |
21 Patients. T—9, C—12. Tx delivered 1 x day x 5 days. χ sites @ χ points. | λ830, 100 mW, fluence 4 J/cm2, Irrad. χ W/cm2, total energy χ J, Beam dia χ, χ cm2, χ s | χ/1 | CT |
| Khouri, 2009 [33] |
RCT Pre-treatment |
22 Patients. T—12, C—10 Tx delivered χ x day x χ days. χ sites @ χ points. | λ660 + 780, CW, in contact, 25 mW, fluence 6.9 J/cm2, Irrad. 0.69 W/cm2, total energy 5.4 J, Beam dia 2 mm, 0.036 cm2, 10 s |
χ/3 | CT CT + RT |
| Silva, 2011 [34] |
RCT B Pre-treatment |
42 Patients. T—21, C—21. Tx delivered 1 x day x 9 days. 10 sites @ 80 points. | λ660, CW, in contact, 40 mW, fluence 11.1 J/cm2, Irrad 1 W/cm2, total energy 12.8 J, Beam dia 2 mm, 0.036 cm2, 10 s | χ/3 | CT CT + RT |
| Lima, 2012 [35] |
RCT DB Pre-treatment |
75 Patients. T—37, C—38. Tx delivered 1 x day x χ days. 9 sites @ χ points. | λ660, CW, in contact, 10 mW, fluence 2.8 J/cm2, Irrad. 0.25 W/cm2, total energy χ J, Beam dia χ, 0.036 cm2, 10 s | 0/2 | RT |
| Oton-Leite, 2012 [36] |
RCT Pre-treatment |
60 Patients. T—30, C—30. Tx delivered 1 x day x χ days. 11 sites @ 55 points. | λ685, CW, in contact, 35 mW, fluence 2 J/cm2, Irrad χ W/cm2, total energy χ J, Beam dia χ mm, χ cm2, χ s | χ/3 | RT |
| Hodgson, 2012 [37] |
RCT DB Post-treatment |
80 Patients. T—40, C—40. Tx delivered 1 x day x 14 days. 3 sites @ χ points. | λ670, CW, in contact, χ mW, fluence 4 J/cm2, Irrad. 0.05 W/cm2, total energy χ J, Beam dia χ, χ cm2, 80 s | 1/0 | CT LED extraoral |
| Carvalho, 2011 [38] |
RCT Pre-treatment |
70 Patients. T(i)—35, T(ii) 35 C—0. Tx delivered 1 x day x χ days. 7 sites @ χ points. | T(i) λ660, CW, in contact, 5 mW, fluence 1.4 J/cm2, Irrad. 0.125 W/cm2, total energy χ J, Beam dia 2 mm, 0.036 cm2, 10 s T(ii) λ660, CW, in contact, 15 mW, fluence 4.2 J/cm2, Irrad. 0.375 W/cm2, total energy χ J, Beam dia 2 mm, 0.036 cm2, 10 s |
1/1 | RT RT + CT |
| Arbabi-Kalati, 2012 [39] |
RCT DB Pre-treatment |
48 Patients. T—24, C—24. Tx delivered χ x day x χ days. χ sites @10 points. | λ630, χ mode, χ contact, 30 mW, fluence 5 J/cm2, Irrad χ W/cm2, total energy χ J, Beam dia χ mm, χ cm2, χ s | 3/2 | CT |
| Antunes, 2013 [40] |
RCT DB Pre-treatment |
94 Patients. T—47, C—47. Tx delivered 1 x day x 5 days. 8 sites @ 72 points. | λ660, CW, in contact, 100 mW, fluence 4.2 J/cm2, Irrad 0.417 W/cm2, total energy 72 J, Beam dia 5 mm, 0.24 cm2, 10 s | 2/3 | CT + RT |
| Oton-Leite, 2013 [41] |
RCT DB Pre-treatment |
60 Patients. T—30, C—30. Tx delivered 1 x day x 30 days. 11 sites @ 54 points. | λ685, CW, 2 mm distance, 35 mW, fluence 23.9 J/cm2, Irrad 1.25 W/cm2, total energy 46.4 J, Beam dia 2 mm, 0.036 cm2, 25 s | 2/2 | RT |
| Oton-Leite, 2015 [42] |
RCT DB Pre-treatment |
30 Patients. T—15, C—15. Tx delivered 3 x day x 21 days. 5 sites @ 43 points. | λ660, CW, in contact, 25 mW, fluence 6.9 J/cm2, Irrad 0.625 W/cm2, total energy 10.75 J, Beam dia 2 mm, 0.036 cm2, 10 s | χ/3 | RT + CT |
| Ferreira, 2016 [43] |
RCT DB Pre-treatment |
35 Patients. T—17, C—18. Tx delivered 1 x day x 5 days. 9 sites @ 27 points. | λ650, CW, in contact, 100 mW, fluence 3.57 J/cm2, Irrad 1.46 W/cm2, total energy 54 J, Beam dia 2 mm, 0.028 cm2, 20 s | 1/2 | CT |
| Amadori, 2016 [44] |
RCT DB Post-treatment |
123 Patients. T—62, C—61. Tx delivered 1 x day x 4 days. χ sites @ χ points. | λ830, 150 mW, χ mode, χ contact, 100 mW, fluence 4.5 J/cm2, Irrad 0.15 W/cm2, total energy χ J, Beam dia χ mm, 1 cm2, 30 s | 1/0 | CT |
| Elad, 2011 [45] |
RCT DB Pre-treatment |
19 Patients. T—10, C—9. Tx delivered 1 x day x 25 days. χ sites @ χ points. | λ650, χ mode, χ contact, χ mW, fluence χ J/cm2, Irrad 0.2 W/cm2, total energy χ J, Beam dia χ mm, χ cm2, 68 s | 1/2 | CT CT + RT LED |
| Gautam, 2013 [46] |
RCT DB Pre-treatment |
220 Patients. T—110, C—110. Tx delivered 1 x day x 32 days. 6 sites @ χ points. | λ632.8, CW, Spot 1 cm, 24 mW, fluence 3.5 J/cm2, Irrad 0.024 W/cm2, total energy 38 J, Beam dia 0.6 mm, 1 cm2, 125 s | 3/3 | CT+RT |
| Gautam, 2015 [3] |
RCT DB Pre-treatment |
46 Patients. T—22, C—24. Tx delivered 1 x day x 5 days. 12 sites @ χ points. | λ632.8, CW, Spot 1 cm, 24 mW, fluence 3 J/cm2, Irrad 0.024 W/cm2, total energy 36 J, Beam dia 0.6 mm, 1 cm2, 125 s | 2/3 | RT |
| Kelner, 2007 [47] |
RCT B Pre-treatment |
49 Patients. T—24, C—25. Tx delivered χ x day x χ days. χ sites @ χ points. | λ685, CW, in contact, 35 mW, fluence 1.1 J/cm2, Irrad χ W/cm2, total energy χ J, Beam dia χ mm, χ cm2, 32 s | χ/1 | RT RT + CT |
| Marin-Conde, 2019 [48] | RCT DB Pre-treatment |
41 Patients. T—26, C—15. Tx delivered χ x day x χ days. χ sites @ 72 points. | λ940, CW, in contact, 500 mW, fluence 83.3 J/cm2, Irrad 13.88 W/cm2, total energy 216 J, Beam dia 2 mm, 0.036 cm2, 6 s | χ/3 | RT + CT |
| Vitale, 2017 [49] |
RCT B Post-treatment |
16 Patients. T—8, C—8 Tx delivered 1 x day x χ days. χ sites @ χ points. | λ970, CW, scanning defocussed, 1600 mW, fluence χ J/cm2, Irrad 1.6 W/cm2, total energy χ J, Beam dia 2 mm, 1 cm2, 240 s | 1/2 | CT Full mouth |
| Salvador, 2017 [50] |
RCT B Pre-treatment |
51 Patients. T—27, C—24. Tx delivered 1 x day x χ days. χ sites @ 80 points. | λ660, CW, in contact, 40 mW, fluence 4 J/cm2, Irrad 1 W/cm2, total energy 12.8 J, Beam dia 2 mm, 0.04 cm2, 4 s | ?/3 | CT |
| Gobbo, 2018 [51] |
RCT BPost-treatment | 101 Patients. T—51, C—50. Tx delivered 1 x day x 4 days. 9 sites @ χ points. | λ660 + 970, gated 50% duty cycle, scanning defocussed, 320 mW, fluence 36.8 J/cm2, Irrad 0.32 W/cm2, total energy 144 J, Beam dia χ mm, 1 cm2, 450 s | 1/3 | CT/RT Full mouth |