Table 3.
Caspase-3 activity and TGF-β1level in the hippocampus and prefrontal of experimental groups were detected by Elisa assay kits. Rats treated with high-fat, high-protein, low-calorie, low-calorie high-protein diets for 10 weeks. Control adult and old rats treated with rodent standard pellet. After behavioral tests, rats were euthanized and brains were collected (n = 3)
| Groups | Caspase-3 (U.g) | TGF-β1(ng.g) | ||
|---|---|---|---|---|
| Hippocampus | Prefrontal cortex | Hippocampus | Prefrontal cortex | |
| Adult-C | 6.1 ± 0.2 | 5.0 ± 0.4 | 6.8 ± 0.2 | 5.0 ± 0.4 |
| Old-C | 6.8 ± 0.3*** | 5.4 ± 0.6 | 2.8 ± 0.3*** | 2.3 ± 0.3*** |
| High-fat | 7.1 ± 0.3 | 6.9 ± 0.2## | 3.2 ± 0.5 | 3.5 ± 0.2# |
| High-protein | 6.5 ± 0.4 | 5.5 ± 0.4 | 5.6 ± 0.5## | 4.1 ± 0.7## |
| Low-calorie | 6.2 ± 0.6# | 4.8 ± 0.3# | 7.1 ± 0.4## | 5.5 ± 0.4## |
| Low-calorie high-protein | 6.0 ± 0.3### | 4.5 ± 0.3### | 7.5 ± 0.8$### | 5.9 ± 0.2$### |
***P < 0.001 versus Adult-C. #P < 0.05, ##P < 0.01, ###P < 0.001 versus Old-C. $P < 0.05 versus high-protein group