TABLE.
Overview of the Quantitative Analysis
| Control |
Type A Cortical Tuber |
Type B Cortical Tuber |
Type C Cortical Tuber |
Perituberal Cortex |
Statistical Significance |
||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Total n | Available n | Median | Min | Max | Total n | Available n | Median | Min | Max | Total n | Available n | Median | Min | Max | Total n | Available n | Median | Min | Max | Total n | Available n | Median | Min | Max | p Value | ||
| T-cells/mm² [CD3] | Gray matter | 39 | 7 | 2.78 | 0.45 | 3.54 | 11 | 11 | 4.12 | 1.00 | 22.07 | 20 | 16 | 11.26 | 0.64 | 43.69 | 15 | 15 | 11.34 | 0.26 | 76.52 | 9 | 7 | 2.77 | 0.98 | 6.84 | 0.011 |
| T-cells/mm² [CD3] | White matter | 39 | 7 | 4.22 | 0.80 | 9.70 | 11 | 11 | 13.76 | 0.33 | 31.66 | 20 | 16 | 20.47 | 3.59 | 80.94 | 15 | 15 | 17.77 | 1.96 | 128.96 | 9 | 7 | 12.71 | 1.46 | 32.04 | 0.011 |
| Neurons/mm² [NeuN] | Gray matter | 39 | 7 | 1499.90 | 1059.00 | 1842.73 | 11 | 11 | 909.64 | 227.98 | 1491.58 | 20 | 17 | 548.63 | 125.10 | 1404.76 | 15 | 15 | 550.64 | 224.04 | 1805.36 | 9 | 8 | 942.93 | 406.39 | 1521.70 | 0.001 |
| Neurons/mm² [NeuN] | White matter | 39 | 7 | 1.60 | 0.20 | 10.40 | 11 | 11 | 38.44 | 9.65 | 123.71 | 20 | 17 | 51.78 | 5.63 | 864.08 | 15 | 15 | 35.94 | 10.80 | 147.40 | 9 | 8 | 46.15 | 10.52 | 123.40 | 0.001 |
| Microglial activation % [Cr3/43] | Gray matter | 39 | 7 | 0.88 | 0.17 | 2.12 | 11 | 11 | 0.61 | 0.09 | 30.37 | 20 | 16 | 2.33 | 0.39 | 26.66 | 15 | 15 | 2.23 | 0.04 | 18.91 | 9 | 9 | 0.71 | 0.01 | 9.05 | 0.144 |
| Microglial activation % [Cr3/43] | White matter | 39 | 7 | 0.92 | 0.52 | 3.91 | 11 | 11 | 1.49 | 0.44 | 7.68 | 20 | 16 | 2.84 | 0.50 | 12.04 | 15 | 15 | 2.33 | 0.10 | 14.02 | 9 | 9 | 1.35 | 0.76 | 5.45 | 0.548 |
| Gliosis % [GFAP] | Gray matter | 11 | 9 | 2.40 | 0.09 | 44.21 | 20 | 17 | 19.87 | 0.27 | 56.04 | 15 | 15 | 12.52 | 1.43 | 73.13 | 9 | 8 | 1.42 | 0.10 | 12.08 | 0.006 | |||||
| Gliosis % [GFAP] | White matter | 11 | 9 | 27.97 | 4.11 | 88.15 | 20 | 17 | 18.41 | 4.71 | 64.93 | 15 | 15 | 11.59 | 1.34 | 62.49 | 9 | 8 | 13.31 | 5.93 | 56.73 | 0.255 | |||||
| Oligodendroglia/mm² [olig2] | Gray matter | 39 | 18 | 243.50 | 158.88 | 394.88 | 11 | 10 | 80.42 | 29.68 | 477.66 | 20 | 16 | 85.06 | 32.54 | 449.56 | 15 | 15 | 122.47 | 56.03 | 520.68 | 9 | 6 | 83.23 | 23.13 | 120.35 | 0.002 |
| Oligodendroglia/mm² [olig2] | White matter | 39 | 31 | 517.00 | 249.66 | 681.50 | 11 | 10 | 412.36 | 145.02 | 624.94 | 20 | 16 | 234.40 | 89.92 | 818.71 | 15 | 15 | 237.28 | 95.03 | 895.57 | 9 | 7 | 590.11 | 176.37 | 907.39 | 0.001 |
| Myelin % [MBP] | Gray matter | 39 | 14 | 0.11 | 0.00 | 10.37 | 11 | 9 | 0.51 | 0.07 | 1.73 | 20 | 15 | 1.79 | 0.02 | 9.01 | 15 | 14 | 0.81 | 0.08 | 9.35 | 9 | 7 | 1.06 | 0.43 | 6.45 | 0.106 |
| Myelin % [MBP] | White matter | 39 | 28 | 93.36 | 56.98 | 99.00 | 11 | 10 | 44.62 | 0.80 | 84.76 | 20 | 16 | 11.24 | 0.03 | 79.77 | 15 | 14 | 7.76 | 0.13 | 61.64 | 9 | 7 | 73.02 | 65.34 | 90.01 | <0.001 |
| Myelin 2% [MOBP] | Gray matter | 39 | 4 | 4.96 | 3.05 | 5.73 | 11 | 2 | 1.31 | 1.01 | 1.60 | 20 | 6 | 10.55 | 0.05 | 25.49 | 15 | 4 | 12.32 | 6.88 | 18.70 | 9 | 2 | 3.43 | 3.20 | 3.66 | 0.086 |
| Myelin 2% [MOBP] | White matter | 39 | 15 | 68.00 | 7.00 | 100.00 | 11 | 2 | 27.03 | 16.93 | 37.13 | 20 | 6 | 4.01 | 0.05 | 17.12 | 15 | 4 | 2.28 | 0.81 | 18.26 | 9 | 2 | 15.05 | 0.44 | 29.66 | 0.002 |
| axons % [SMI31] | White matter | 39 | 7 | 67.30 | 24.10 | 77.70 | 11 | 4 | 53.91 | 29.91 | 58.60 | 20 | 2 | 30.04 | 24.97 | 35.10 | 15 | 2 | 47.73 | 41.80 | 53.66 | 9 | 3 | 34.65 | 23.41 | 83.43 | 0.126 |
| Nodes of Ranvier IOD [CASPR] | White matter | 39 | 5 | 5648.66 | 1831.33 | 9305.75 | 20 | 2 | 1483.77 | 956.88 | 2010.66 | 15 | 3 | 1368.21 | 1129.60 | 1563.58 | 0.016 | ||||||||||
All values are represented in median, minimum, and maximum. The total number of cases within the subgroup is shown as well as the number of cases available for the specific analysis. Significance level shown based on Kruskal-Wallis test except for [SMI31] and [CASPR], these are based on Mann-Whitney-U testing. Values considered significant < 0.05.
WM, white matter; GM, gray matter; olig2, oligodendroglia; MOBP, myelin associated oligodendrocyte basic protein; MBP, myelin basic protein; GFAP, glial fibrillary acidic protein; n, number; min, minimum; max, maximum.