Skip to main content
. Author manuscript; available in PMC: 2020 Oct 15.
Published in final edited form as: Science. 2020 Jun 5;368(6495):1081–1085. doi: 10.1126/science.aaz9649

Fig. 1. Cryo-EM structure of human CST decameric supercomplex and its architecture.

Fig. 1.

(A) Cryo-EM density of decameric CST complex colored by segmented CST monomers. (B) Docking of available atomic models of a CTC1 OB-domain [*reported as central domain OB-fold (25), PDB 5W2L], STN1n (N-terminal half, PDB 4JOI:A), STN1c (C-terminal half, PDB 4JQF), and TEN1 (PDB 4JOI:C). (C) Structure-based schematic of CST domain architecture and intermolecular interactions between subunits. The individual OB domains of CTC1 are rainbow colored. (D) CTC1 architectural organization of seven OB domains (A to G) and the identified bound-ssDNA (space-filled model). Spokes in (A) are STN1c, whereas the legs are CTC1 OB-A, -B, and -C.