ADCC	Antibody-Dependent Cellular Cytotoxicity
APC	Antigen-presenting cell
B6	C57BL/6
CDC	Complement-Dependent Cytotoxicity
CFA	Complete Freund’s Adjuvant
CSF	Cerebrospinal Fluid
CNS	Central Nervous System
CD20	Cluster of Differentiation 20
CD20dbtg	Double Transgenic huCD20xHIGR3 Mice
CD20dbtg1	First Double Transgenic Cohort
CD20dbtg2	Second Double Transgenic Cohort
ddH2O	Double-distilled water
EAE	Experimental Autoimmune Encephalomyelitis
EDSS	Expanded Disability Status Scale
huCD20	Anti-human CD20
huIgG1	Human IgG1 Isotype Control Antibody
mAb	Monoclonal Antibody
MBP	Myelin Basic Protein
MP4	Myelin Basic Protein/Proteolipid Protein Fusion Protein
MS	Multiple Sclerosis
muIgG2a	Murine IgG2a Isotype Control Antibody
NF	Neurofilament
NfL	Neurofilament Light Chain
OBZ	Obinutuzumab
PBS	Phosphate-Buffered Saline
PLP	Proteolipid Protein
NfL	Neurofilament Light Chain
PFA	Paraformaldehyde
SPMS	Secondary Progressive Multiple Sclerosis
TEM	Transmission Electron Microscopy
VLT	Ventrolateral Tract of the Spinal Cord
wt	Wildtype Cohort