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Binding kinetics of FabA and FabB to albumin of different species.
| Compound | HSA | CSA | RSA | PSA | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ka (1/Ms) | kd (1/s) | KD (nM) | ka (1/Ms) | kd (1/s) | KD (nM) | ka (1/Ms) | kd (1/s) | KD (nM) | ka (1/Ms) | kd (1/s) | KD (nM) | |
| FabA | 110,000 ± 10,000 | 0.0061 ± 0.0001 | 55 ± 6 | 99,000 ± 4000 | 0.0065 ± 0.0004 | 66 ± 6 | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. |
| FabB | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. |
n.d.: no detectable interaction.
