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Permeation parameters of diclofenac sodium through cellulose membrane, heat-separated human epidermis and skin parallel artificial membrane permeability assay (PAMPA) membrane after 6 h.
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Q, cumulative amount of diclofenac sodium penetrated per cm2 at 6 h (mean ± SD, n = 6); J, flux determined from the slope of the cumulative amounts of diclofenac sodium permeated (µg/cm2) versus time (h) profiles; * p < 0.05, ***, p < 0.001.
