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. Author manuscript; available in PMC: 2020 Oct 15.
Published in final edited form as: Cell Stem Cell. 2020 Sep 3;27(3):361–365. doi: 10.1016/j.stem.2020.08.013

Figure 1. Cellular Identity in Primary Tissue to Improve Organoid Models.

Figure 1.

Many aspects of a cell within a primary tissue define its cell identity. Characterizing each of these properties in primary tissues is essential to measuring and optimizing them in organoid models. These datapoints include characterization of the cell type via methods including transcriptome, epigenome, and protein abundance; cytoarchitectural organization including parameters of spatial organization, morphology, and physical connectivity; and metrics of cellular and tissue function including metabolic state and electrophysiology.