Table 2.
Minimal inhibitory concentration (MIC, µM and g/L) for representative pathogenic microorganisms, and half maximal inhibitory concentration (IC50, µM and g/L) against epimastigote forms of T. cruzi displayed by Figainin 1.
| Figainin 1 | ||
|---|---|---|
| Microorganisms | µM | g/L |
| Gram-positive bacteria (MIC) | ||
| E. faecalis (ATCC 29212) | 8 | 0.015 |
| S. aureus (ATCC 25923) | 4 | 0.008 |
| S. epidermidis (ATCC 12228) | 2 | 0.004 |
| E. casseliflavus (ATCC 700327) | 16 | 0.030 |
| Gram-negative bacteria (MIC) | ||
| E. coli (ATCC 25922) | 16 | 0.030 |
| P. aeruginosa (ATCC 27853) | NA a | NA a |
| K. pneumoniae (ATCC 13883) | 4 | 0.008 |
| Yeast (MIC) | ||
| C. albicans (ATCC 90028) | NA a | NA a |
| C. parapsilosis (ATCC 22019) | NA a | NA a |
|
Trypanosoma epimastigotes (IC50)
T. cruzi |
15.9 | 0.030 |
a NA: no activity observed at a maximum concentration of 64 µM (0.123 g/L).