Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 15;10:29. doi: 10.1186/s13395-020-00251-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 1 — Cayman Chemical Epigenetic Screening Library chemical-combination pooling scheme. a The library consists of 2 96-well plates (P1, P2). See Table 1 for the list of chemicals. Gray X’s mark empty wells. Blue X’s mark wells with chemicals not used in our screen: CAY10669, (−)-JQ1, MI-nc, GSK-J1, GSK-J2, and GSK-J5. Pooling process for plate 1 well A2 chemical (3-amino benzamide; yellow well) is illustrated. b Grid representation of the library chemicals and pools, in which each chemical (88 out of 94 total library chemicals) is represented along both the x- and y-axes. CAY10669, (−)-JQ1, MI-nc, GSK-J1, GSK-J2, and GSK-J5 are removed from this grid representation. Shading (dark blue/light blue, dark gray/light gray) represents rows of chemicals in the library plates. Each horizontal, alternately shaded row represents a candidate chemical pool. Blue shading represents the 93 pools tested. Gray shading represents the remaining candidate pools (403 total pools on this grid)