Table 1.

Polymorphisms on immune-related genes in Brazilian patients with PCM.

Structure (gene)	Mutation (rs)	Main results	References
CTLA-4 (CTLA4)	−318 C/T and +49 A/Ga	• No differences between patients and controls	(48)
DC-SIGN (DCSIGN)	rs4804803	• Genotype DCSIGN-GG on patients with oral PCM (p = 0.032)	(49)
FCγ-RIIa (FCGR2A)	rs1801274	• No differences between patients and controls	(49)
HLA (HLA)	HLA-DRB1 and HLA-DQB1 allelesa	• HLA-DRB1*11 allele associated with UC form of PCM (p = 0.039)	(26)
IFN-γ (IFNG)	+874 T/Aa	• No differences between patients and controls	(35)
	+874 T/A (rs2430561)	• No differences between patients and controls	(31)
		• No differences between clinical forms of PCM
IL-4 (IL4)	−590 T/Ca	• Patients with C-allele produce more IL-4 than those with T-allele (p < 0.05)	(35)
		• No differences between patients and controls	(30)
	Intron-3 microsatellite RP1/RP2a	• Genotypes RP2/RP2 on patients and RP1/RP1 on controls (with low IL-4 expression): p = 0.0042	(30)
IL-10 (IL10)	−1082 G/Aa	• Genotypes IL10-GG on patients and IL10-AA on controls (p = 0.0218)	(34)
IL-12p40 (IL12B)	+1188 A/C (rs3212227)	• No differences between patients and controls	(31)
		• No differences between clinical forms of PCM
IL-12Rβ1 (IL12RB1)	230 T/C Leu77Phea	• Inherited IL-12Rβ1 deficiency leading to acute form of PCM	(29)
	641 A/G (rs11575834)	• No differences between patients and controls	(31)
		• Male patients: Genotype IL12RB1-AA on MC form and IL12RB1-AG on UC form (p = 0.048)
JAK1	rs11208534	• No differences between patients and controls	(49)
TNF-α (TNFA)	−308 G/Aa	• No differences between patients and controls	(34)
	rs1800629	• No differences between patients and controls	(49)
Vitamin D Receptor (VDR)	rs7975232	• Genotype VDR-CC (p < 0.001) and C-allele (p = 0.027) on patients	(49)

^ars not informed or not applicable.