Table 3.
Genotypic and allelic distributions and frequencies of IL12A-504 G/T, IL18-607 C/A, and IFNGR1-611 A/G SNPs, values of Odds Ratio (OR) and 95% Confidence Interval (95% CI) among the groups of Controls (n = 110) and Patients (n = 149), and among the groups of patients with Acute (n = 39) and Chronic (Multifocal + Unifocal) forms of PCM (n = 110).
| SNP | Genotypes | Alleles | Groups—n (%) | Clinical forms of PCM—n (%) | ||||
|---|---|---|---|---|---|---|---|---|
| Controls | Patients | OR (95% CI) | Acute | Chronic | OR (95% CI) | |||
| IL12A-564 G/T | GG | 2 (1.8) | 2 (1.3) | 1.0 | 1 (2.6) | 1 (0.8) | 1.0 | |
| GT | 28 (25.5) | 40 (26.9) | 1.43 (0.19–10.76) | 13 (33.4) | 27 (24.6) | 0.48 (0.03–8.32) | ||
| TT | 80 (72.7) | 107 (71.8) | 1.34 (0.18–9.7) | 25 (64.0) | 82 (74.6) | 0.3 (0.02–5.05) | ||
| G | 32 (14.5) | 44 (14.8) | 1.0 | 15 (19.2) | 29 (13.2) | 1.0 | ||
| T | 188 (85.5) | 254 (85.2) | 0.98 (0.6–1.61) | 63 (80.8) | 191 (86.8) | 0.63 (0.32–1.26) | ||
| IL18-607 C/A | CC | 29 (26.4) | 44 (29.5) | 1.0 | 10 (25.7) | 34 (30.9) | 1.0 | |
| CA | 60 (54.5) | 68 (45.6) | 0.75 (0.42–1.34) | 16 (41.0) | 52 (47.3) | 1.05 (0.43–2.58) | ||
| AA | 21 (19.1) | 37 (24.8) | 1.16 (0.57–2.37) | 13 (33.3) | 24 (21.8) | 1.84 (0.7–4.89) | ||
| C | 118 (53.6) | 156 (52.3) | 1.0 | 36 (46.2) | 120 (54.5) | 1.0 | ||
| A | 102 (46.4) | 142 (47.7) | 1.05 (0.74–1.49) | 42 (53.8) | 100 (45.5) | 1.4 (0.83–2.35) | ||
| IFNGR1-611 A/G | AA | 14 (12.8) | 21 (14.1) | 1.0 | 4 (10.3) | 17 (15.5) | 1.0 | |
| AG | 47 (43.1) | 66 (44.3) | 0.93 (0.43–2.03) | 19 (48.7) | 47 (42.7) | 0.58 (0.17–1.96) | ||
| GG | 48 (44.0) | 62 (41.6) | 0.86 (0.4–1.87) | 16 (41.0) | 46 (41.8) | 0.67 (0.2–2.3) | ||
| A | 75 (34.4) | 108 (36.2) | 1.0 | 27 (34.6) | 81 (36.8) | 1.0 | ||
| G | 143 (65.6) | 190 (63.8) | 0.92 (0.64–1.33) | 51 (65.4) | 139 (63.2) | 1.1 (0.64–1.89) | ||