Table 3.
Outcomes of heparin versus. standard ATT group in the matched population
| Outcome variable | Early IVH group | Standard ATT group | Binary logistic analysis | |
|---|---|---|---|---|
| OR (95% CI) | P value | |||
| Efficacy outcome | ||||
| Neurological improvement at 24 hr | 62/117 (53.0) | 78/233 (33.5) | 2.24 (1.42, 3.53) | <0.01 |
| Neurological improvement at 7 d a | 74/117 (63.2) | 110/233 (47.2) | 1.92 (1.22, 3.03) | <0.01 |
| Excellent recovery at 90 d | 52/117 (44.4) | 74/230 (32.2) | 1.69 (1.07, 2.67) | 0.03 |
| Functional independence at 90 d | 66/117 (56.4) | 97/230 (42.2) | 1.77 (1.13, 2.78) | 0.01 |
| Safety outcome | ||||
| sICH within 7 d a | 6/117 (5.1) | 13/234 (5.6) | 0.92 (0.34, 2.48) | 0.87 |
| aICH within 7 d a | 26/117 (22.2) | 36/234 (15.4) | 1.57 (0.90, 2.76) | 0.12 |
| Mortality within 90 d | 10/117 (8.5) | 40/230 (17.4) | 0.44 (0.21, 0.92) | 0.03 |
Data are event number/total number (%), unless otherwise indicated.
sICH was evaluated by using the European Cooperative Acute Stroke Study (ECASS) definition, which was defined as any intracranial hemorrhage associated with 4 or more points of worsening on NIHSS. aICH was verified by follow‐up imaging studies regardless of any clinical deterioration. Neurological improvement was defined as NIHSS score decrease of ≥ 4 points from the baseline. Excellent recovery was defined as having a mRS score of 0–1, and functional independence was defined as having a mRS score of 0–2.
Abbreviations: aICH, any intracranial hemorrhage, ATT, antithrombotic therapy, CI, confidence interval, IVH, intravenous heparin, OR, odds ratio, sICH, symptomatic intracranial hemorrhage.
At 7 d or discharge, whichever comes first.