Table 3.
mTOR gene polymorphism vs. tuberculosis incidence
|
TB patients |
Healthy controls |
ORc (95%CI) | ORa1 (95%CI) | ||||
| n | % | n | % | ||||
| rs2295080 | TT | 286 | 56.86 | 323 | 65.38 | 1 | 1 |
| GT | 191 | 37.97 | 158 | 31.98 | 1.365 (1.048-1.778) | 1.334 (1.018-1.749)a | |
| GG | 26 | 5.17 | 13 | 2.63 | 2.259 (1.139-4.479) | 2.224 (1.110-4.458)a | |
| GT + GG | 217 | 43.14 | 171 | 34.61 | 1.433 (1.110-1.851) | 1.403 (1.080-1.823)a | |
| rs2024627 | CC | 406 | 80.72 | 429 | 86.84 | 1 | 1 |
| CT | 93 | 18.49 | 63 | 12.75 | 1.560 (1.102-2.208) | 1.562 (1.096-2.226)a | |
| TT | 4 | 0.80 | 2 | 0.40 | 2.113 (0.385-11.600) | 2.069 (0.369-11.607) | |
| CT + TT | 97 | 19.29 | 65 | 13.15 | 1.577 (1.120-2.220) | 1.578 (1.113-2.237)a | |
| rs1057079 | TT | 271 | 53.88 | 330 | 66.80 | 1 | 1 |
| CT | 204 | 40.56 | 152 | 30.77 | 1.634 (1.255-2.129) | 1.597 (1.216-2.097)a | |
| CC | 28 | 5.57 | 12 | 2.43 | 2.841 (1.418-5.694) | 2.858 (1.404-5.818)a | |
| CT + CC | 232 | 46.13 | 164 | 33.20 | 1.723 (1.333-2.226) | 1.682 (1.290-2.194)a | |
| rs12137958 | GG | 414 | 82.31 | 419 | 84.82 | 1 | 1 |
| AG | 87 | 17.30 | 72 | 14.57 | 1.223 (0.870-1.719) | 1.187 (0.840-1.678) | |
| AA | 2 | 0.40 | 3 | 0.61 | 0.675 (0.112-4.059) | 0.879 (0.144-5.379) | |
| AG + AA | 89 | 17.70 | 75 | 15.18 | 1.201 (0.858-1.680) | 1.176 (0.836-1.656) | |
| rs7525957 | TT | 368 | 73.16 | 402 | 81.38 | 1 | 1 |
| CT | 126 | 25.05 | 86 | 17.41 | 1.600 (1.176-2.179) | 1.559 (1.138-2.136)a | |
| CC | 9 | 1.79 | 6 | 1.21 | 1.639 (0.578-4.648) | 1.686 (0.588-4.831) | |
| CT + CC | 135 | 26.84 | 92 | 18.62 | 1.603 (1.187-2.165) | 1.568 (1.154-2.130)a | |
a
P < 0.05.
1
Adjusted for the covariates of sex, age, marital status, educational background, body mass index, smoking status, alcohol drinking, tea drinking and Bacillus Calmette–Guérin vaccination. TB: Tuberculosis.