Table 3.
Tabular summary of the in vivo bone healing analysis. The color coding is based on the values obtained in the different analysis. Grey: absent bridging/low values, blue: intermediate values/similar outcomes between groups, green observed bridging/finer callus and high values. Empty: untreated control, BC: blood clot, SD-MBG: spray-dried mesoporous bioactive glass; BMP-2: bone morphogenetic protein 2, *: significantly different to the BC + SD-MBG group (* p < 0.05).
| Empty | BC | BC + SD-MBG | BC + SD-MBG + BMP-2 | |
|---|---|---|---|---|
| Bridging | No | No | No | Complete/partial |
| Bone volume | Low | Low | Low | * High |
| Tissue volume | Low | Low | Low | * High |
| Bone microarchitecture | Similar | Similar | Similar | * Finer |
| Connective tissue area | Intermediate | High | High | * Low |
| Cartilage tissue area | High | Low | Low | Low |
| Vessel area | Intermediate | Low | High | Intermediate |
| Osteoclastic (CD68+) cells bone coverage | Similar | Similar | Similar | Similar |