Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Aug 21;12(9):793. doi: 10.3390/pharmaceutics12090793

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Human alpha1 antitrypsin (AAT) expression 30 days after in vivo intrahepatic electroporation-mediated hAAT gene transfer: (a) hAAT levels in serum and liver homogenates, mean ± SD; (b) representative immunofluorescent images of the liver 30 days after intrahepatic electroporation-mediated gene transfer, green fluorescence: hAAT. Electroporation-mediated gene transfer is safe in the liver. Serum levels of liver enzymes were measured: (c) serum aspartate aminotransferase (AST), (d) serum alanine aminotransferase (ALT), and (e) serum albumin. Values are expressed as mean and ± SD; all the values are within physiological range. Sirius red staining of the liver section did not show any sign of liver injury or fibrosis after electroporation-mediated gene transfer as observed by Ishak system staining [23]. Wildtype (f), pallid (g), empty vector (h), and pEF-hAAT (i).

Human alpha1 antitrypsin (AAT) expression 30 days after in vivo intrahepatic electroporation-mediated hAAT gene transfer: (a) hAAT levels in serum and liver homogenates, mean ± SD; (b) representative immunofluorescent images of the liver 30 days after intrahepatic electroporation-mediated gene transfer, green fluorescence: hAAT. Electroporation-mediated gene transfer is safe in the liver. Serum levels of liver enzymes were measured: (c) serum aspartate aminotransferase (AST), (d) serum alanine aminotransferase (ALT), and (e) serum albumin. Values are expressed as mean and ± SD; all the values are within physiological range. Sirius red staining of the liver section did not show any sign of liver injury or fibrosis after electroporation-mediated gene transfer as observed by Ishak system staining [23]. Wildtype (f), pallid (g), empty vector (h), and pEF-hAAT (i).