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Flowchart representing the case selection process used in the current study. From 300 dogs living in an endemic area of zoonotic visceral leishmaniosis (ZVL) diagnosed with canine leishmaniosis (CanL), 99 dogs were selected and evaluated. Dogs were treated with miltefosine in combination with allopurinol (M + A), meglumine antimoniate in association with allopurinol (Me + A), allopurinol in monotherapy (A) or aminosidine in combination with allopurinol (Am + A).
