Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
SARS-COV-2 infection pathway. (1). SARS-CoV-2 has a spike glycoprotein that must first be cleaved by TMPRSS2. (2). Spike protein interacts with CD147 or Angiotensin Converting Enzyme 2 (ACE-2). (3). The virus is endocytosed and cathepsin L (CTSL) must further cleave the virus. (4). The virus fuses with the endosome membrane, thereby releasing single stranded RNA (ssRNA) into the cytosol.
