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. 2020 Sep 10;12(9):863. doi: 10.3390/pharmaceutics12090863

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Uptake of platinum by cancer and noncancer cells. (A) Total platinum uptake (ng) in samples of one million treated cells accurately quantified by ICP MS. (B) Platinum uptake ratios (intracellular: extracellular platinum) in cancer and noncancer cells. In both cases, a statistically significant increase in cellular uptake of platinum with PEGylated liposomal nedaplatin (LND) compared to ND was observed specifically in the cancer cells lines (p-value < 0.05). Multiple pair-wise t-tests showed the cell lines where a significant difference in platinum uptake between LND and ND was observed. These points are indicated by asterisks * (p < 0.05) in the charts above.