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. 2020 Sep 10;12(9):863. doi: 10.3390/pharmaceutics12090863

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Genotoxicity of free and liposomal ND in different cell lines assessed through micronucleus formation induction. (A) Representative image of MNi. (B) A549; (C) U2OS and (D) WI-38 shows a significant increase in MNi induction between free and liposomal ND in cancer cell lines A and B, but not in normal cell lines, D. Multiple pair-wise t-tests show the concentrations at which a significant difference between both drugs was observed. These points are indicated by asterisks * (p < 0.05). Scale bars are 5 µm.

Genotoxicity of free and liposomal ND in different cell lines assessed through micronucleus formation induction. (A) Representative image of MNi. (B) A549; (C) U2OS and (D) WI-38 shows a significant increase in MNi induction between free and liposomal ND in cancer cell lines A and B, but not in normal cell lines, D. Multiple pair-wise t-tests show the concentrations at which a significant difference between both drugs was observed. These points are indicated by asterisks * (p < 0.05). Scale bars are 5 µm.