Fig. 1.

RUNX2 possibly monitors the sphere-forming ability of CRC cells by targeting CD44. a Endogenous expression of RUNX2 in different CRC cells. b The analysis of sphere-forming ability by sphere formation assays in RKO cells under different conditions. c The analysis of sphere-forming ability by sphere formation assays in HT115 cells under different conditions. d Western blotting results showing that RUNX2 can regulate the CD44 expression. Data are shown as means ± SE; *P<0.05, **P<0.01; NC negative control, si short interfering, RUNX2 overexpression of RUNX2