Table 3.

Inhibitory effects of various cationic drugs to hOCT1- and hOCT2-mediated ³H-MPP uptake and MATE1-mediated ¹⁴C-metformin uptake.

Drugs (14)	Inhibitory Effects (%)
	hOCT1		hOCT2		hMATE1
	10 µM	100 µM	10 µM	100 µM	10 µM	100 µM
Decynium22 *	87	90	42	90	76	97
Clonidine	73	83	69	80	24	60
Ketoconazol *	47	83	33	64	87	98
Verapamil *	39	82	35	43	44	82
Elacridar	31	57	−5	14	42	71
Quinidine *	13	53	0	24	11	24
Procainamide *	10	43	22	38	22	30
Ritonavir *	17	39	15	24	69	91
Ranitidine *	10	38	9	30	19	76
Zosuquidar	2	20	−19	14	23	65
Metformin *	11	13	10	6	5	36
Amiodarone *	9	10	9	19	1	12
CyclosporinA	10	7	−26	−27	18	6
Reserpine	7	6	3	8	72	83

* Asterisks show the compounds which are already published to interact with hOCT1 but not with all rodent Oct1 [8,19,20].