Fig. 4.
Antitumor activity of 60-mG2a-f against MIA PaCa-2 xenograft. (A) Tumor volume of MIA PaCa-2 xenografts. MIA PaCa-2 cells were injected subcutaneously into female nude mice into the 60-mG2a-f group (n = 8) and the control IgG group (n = 8). The indicated antibodies (100 μg/day; 5 mg/kg) were administered intraperitoneally 1, 8, and 15 days after cancer cell inoculation. The tumor volume was measured at the indicated time points. The values are means ± SEM. (B) Tumor weight of MIA PaCa-2 xenografts (day 22). The values are means ± SEM. An asterisk indicates statistical significance (*P < 0.05, **P < 0.01, ***P < 0.005, Tukey-Kramer's test). (C) Resected tumors of MIA PaCa-2 xenografts (day 22).