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NJ phylogenic tree of all (A) human and yeast PDEs and (B) without yPDE1; (C) detail of MUSCLE multiple alignment for all PDEs; indicated, the yPDE1 active site; (D) detail of MUSCLE multiple alignment for all PDEs without yPDE1; indicated, the yPDE2 active site; (E) pairwise alignment between yeast yPDE2 and human PDE4A; indicated the active sites.
