Table 4.

Prognostic analysis on 3-year DFS in patients with colorectal cancer.

Variables		Univariate analysis		Multivariate analysis
		HR (95%CI)	P value	HR (95%CI)	P value
Incisional SSI		0.581 (0.213–1.588)	0.290
Organ/space SSI		1.492 (0.603–3.693)	0.387
Incisional+organ/space SSI		2.794 (1.624–4.806)	<0.001	4.000 (1.459–10.964)	0.007
Sex	F	Ref.
	M	1.006 (0.669–1.514)	0.977
Age ≥60 (year)		1.596 (1.073–2.376)	0.021	1.880 (1.207–2.929)	0.005
Tumor location	Colon	Ref.
	Rectum	0.786 (0.524–1.177)	0.242
Tumor size (cm)	<5	Ref.
	≥5	1.297 (0.869–1.935)	0.203
Tumor differentiation	poor	Ref.		Ref.
	high	0.568 (0.332–0.971)	0.039	0.932 (0.506–1.718)	0.823
Lymph node involvement		3.280 (2.141–5.025)	<0.001	2.968 (1.818–4.847)	<0.001
Depth of tumor	T1–T2	Ref.		Ref.
	T3–T4	4.796 (1.950–11.796)	<0.001	3.789 (1.166–12.307)	0.027
Operative approach	open	Ref.		Ref.
	Lap	0.553 (0.372–0.823)	0.003	0.693 (0.447–1.074)	0.101
Anastomotic leakage		1.839 (1.076–3.144)	0.026	0.557 (0.178–1.743)	0.315
Adjuvant chemotherapy		0.796 (0.535–1.183)	0.259
Preoperative obstruction		1.277 (0.837–1.948)	0.256
Vascular invasion		1.631 (1.047–2.541)	0.031	0.817 (0.482–1.386)	0.454
Perineural invasion		1.860 (1.219–2.838)	0.004	1.372 (0.858–2.192)	0.186
Blood transfusion		1.493 (0.990–2.252)	0.056
Preoperative CEA (ng/ml)	<5	Ref.		Ref.
	≥5	1.545 (1.037–2.304)	0.033	1.079 (0.684–1.701)	0.774
Preoperative CA125 (ng/ml)	<35	Ref.
	≥35	2.271 (1.289–4.003)	0.005	1.660 (0.873–3.159)	0.122
Preoperative CA199 (ng/ml)	<37	Ref.
	≥37	1.733 (1.050–2.861)	0.031	1.088 (0.622–1.901)	0.768

HR – hazard ratio; CI – confidence interval; SSI – surgical site infection; F – Female; M – Male; Lap – laparoscopic.