Table 5.

Prognostic analysis on OS in patients with colorectal cancer.

Variables		Univariate analysis		Multivariate analysis
		HR (95%CI)	P value	HR (95%CI)	P value
Incisional SSI		0.598 (0.219–1.635)	0.316
Organ/space SSI		1.222 (0.446–3.351)	0.696
Incisional+organ/space SSI		3.164 (1.862–5.377)	<0.001	3.694 (1.346–10.138)	0.011
Sex	F	Ref.
	M	1.081 (0.719–1.626)	0.708
Age ≥60 (year)		2.026 (1.352–3.036)	0.001	1.941 (1.197–3.147)	0.007
Tumor location	Colon	Ref.
	Rectum	0.841 (0.561–1.260)	0.402
Tumor size (cm)	<5	Ref.
	≥5	1.274 (0.850–1.910)	0.242
Tumor differentiation	poor	Ref.
	high	0.637 (0.367–1.105)	0.109
Lymph node involvement		2.935 (1.921–4.484)	<0.001	2.632 (1.625–4.262)	<0.001
Depth of tumor	T1–T2	Ref.		Ref.
	T3–T4	3.947 (1.727–9.021)	0.001	2.961 (1.043–8.405)	0.041
Operative approach	open	Ref.		Ref.
	Lap	0.537 (0.361–0.800)	0.002	0.681 (0.439–1.057)	0.087
Anastomotic leakage		1.937 (1.133–3.312)	0.016	0.662 (0.213–2.055)	0.475
Adjuvant chemotherapy		0.634 (0.426–0.945)	0.025	0.598 (0.372–0.964)	0.035
Preoperative obstruction		1.184 (0.770–1.821)	0.442
Vascular invasion		1.780 (1.140–2.781)	0.011	0.943 (0.547–1.625)	0.832
Perineural invasion		2.032 (1.326–3.112)	0.001	1.510 (0.936–2.434)	0.091
Blood transfusion		1.306 (0.858–1.987)	0.213
Preoperative CEA (ng/ml)	<5	Ref.		Ref.
	≥5	1.711 (1.147–2.553)	0.009	1.129 (0.716–2.553)	0.603
Preoperative CA125 (ng/ml)	<35	Ref.		Ref.
	≥35	3.106 (1.811–5.326)	<0.001	1.892 (1.027–3.485)	0.041
Preoperative CA199 (ng/ml)	<37	Ref.		Ref.
	≥37	2.001 (1.234–3.246)	0.005	1.381 (0.803–2.377)	0.243

SSI –surgical site infection; HR – hazard ratio; CI – confidence interval; F – Female; M – Male; Lap – laparoscopic.