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. 2020 Oct 15;39:217. doi: 10.1186/s13046-020-01713-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Expression of AXL and TYRO3 is elevated in alpelisib-resistant cells. a Immunoblot with/without 5 μM alpelisib (36 h) in parental and resistant Cal33 and 93-VU-147T cell lines using indicated antibodies. Densitometric quantification of each protein relative to α-tubulin is shown below each band. b Heatmaps displaying RPPA results (top 50% of differentially-expressed proteins for each cell line is shown). Arrows indicate AXL and TYRO3. c Immunoblot showing expression of TAM family RTKs AXL, TYRO3 and MER-TK in parental and alpelisib-resistant HNSCC cell lines. HEK293T cells are included as a positive control for MER-TK expression. Densitometric quantification of each protein relative to α-tubulin is shown below each band