Table 5.
Subgroup analysis for the type of surgery, device, the goal-directed haemodynamic therapy intervention (fluids only or fluids and inotropes or vasopressors) and the date when the study was conducted. CI confidence interval, M-H Mantel-Haenszel, PAC pulmonary artery catheter
| Subgroups | No. of studies | No. of patients | Analysis | Effect (95% CI) |
P value |
|---|---|---|---|---|---|
| Surgery types | |||||
| General/mixed/abdominal | 44 | 7420 | M-H odds ratio | 0.76 (0.58–0.99) | P = 0.04 |
| Orthopaedic | 9 | 900 | M-H odds ratio | 1.15 (0.73–1.81) | P = 0.54 |
| Cardiothoracic | 7 | 797 | M-H odds ratio | 0.33 (0.17–0.63) | P = 0.0009 |
| Vascular | 6 | 431 | M-H odds ratio | 0.79 (0.35–1.76) | P = 0.56 |
| Device types | |||||
| Minimally invasive | 33 | 3719 | M-H odds ratio | 0.73 (0.53–1.01) | P = 0.06 |
| Oesophageal doppler | 17 | 2003 | M-H odds ratio | 0.87 (0.43–1.77) | P = 0.70 |
| Non-invasive | 5 | 744 | M-H odds ratio | 0.77 (0.44–1.38) | P = 0.38 |
| PAC | 8 | 2688 | M-H odds ratio | 0.69 (0.44–1.08) | P = 0.10 |
| Oxygen indices | 3 | 460 | M-H odds ratio | 1.13 (0.64–2.00) | P = 0.67 |
| Intervention per protocol | |||||
| Fluids only | 22 | 2033 | M-H odds ratio | 1.39 (0.89–2.16) | P = 0.14 |
| Fluid and inotropes or vasopressors | 44 | 7515 | M-H odds ratio | 0.62 (0.49–0.80) | P = 0.0002 |
| Date of study publication | |||||
| Conducted up to and year 2000 | 9 | 728 | M-H odds ratio | 0.54 (0.36–0.81) | P = 0.003 |
| Conducted between 2001 and 2010 | 12 | 3296 | M-H odds ratio | 0.86 (0.56–1.31) | P = 0.48 |
| Conducted between 2011 and to date | 45 | 5524 | M-H odds ratio | 0.73 (0.54–0.99) | P = 0.04 |