Table 3.

AMP’s advantages versus their disadvantages.

Advantages	Disadvantages
Several AMPs show broad and simultaneous activities against bacteria, fungi, viruses, and in case of infection with multiple microorganisms, one AMP could be efficient to overcome this issue.	AMPs are susceptible to proteolytic degradation, which leads to the loss of biological activity.
Natural AMPs are already found in high doses at the site of infection.	Some AMPs can be toxic to mammal cells at high concentrations.
Some AMPs have wound-healing and angiogenesis promotion properties, which are essential in case of hard-to-heal and infected wounds, such as diabetes and foot ulcer.	AMPs can induce hypersensitivity reactions after application.
AMPs show as well anti-inflammatory properties by modulating immune cytokines, which are responsible for the inflammatory response.	AMPs can be influenced by pH variation and at low concentration of salt can be destabilized, leading to loss of activity.
AMPs exhibit therapeutic antimicrobial activity at extremely low concentrations in the microscale and sometimes nanoscale range.	AMP’s production and purification costs are high.
Resistance to AMPs is very low and only in a limited number of AMPs.
AMPs showed to be time-efficient; some AMPs can act within a few seconds to a few minutes.
AMPs inhibit biofilm formation, which is especially important to prevent bacterial growth on medical devices.
AMPs show synergism when chemically coupled to polymers, encapsulated into different delivery systems or simultaneously applied with antimicrobial agents.
AMPs can act synergistically with antibiotics.