Fig. 6.

Exosomes derived from WJ-MSCs modulate inflammation via BKCa channels. a The colocalization of exosomes with the nuclei (DAPI, blue) of THP-1 cells incubated with PKH67 (green)-labelled exosomes was determined using fluorescence microscopy. b, e The expression ofIL-6 (b) and IL-10 (c) mRNAs was detected using real-time PCR, and the levels of the IL-6 (d) and IL-10 (e) proteins were determined using ELISAs. The data are presented as the mean ± S.E.M. from three independent experiments. *p < 0.05, **p < 0.01, and *** p < 0.001 compared with the C group. ^#p < 0.05, ^##p < 0.01, and ^###p < 0.001 compared with the LPS group. ^&p < 0.05, ^&&p < 0.01, and ^&&&p < 0.001 compared with the LPS+ne group