. 2020 Oct 12;8:e10181. doi: 10.7717/peerj.10181

Table 1. Comparisons of MoE and nsp mutations.

NSP	Mutations	Values	MoE absent		MoE present		Total		p
NSP	Mutations	Values	n	%	n	%	n	%	p
nsp7	11916C>T S3884L	Absent	26,326	98.4	2,833	99.7	29,159	98.5	<0.001*
	11916C>T S3884L	Present	433	1.6	8	0.3	441	1.5	<0.001*
	12076C>T N3937N	Absent	26,735	99.9	2,837	99.9	29,572	99.9	0.339
	12076C>T N3937N	Present	24	0.1	4	0.1	28	0.1	0.339
	11919C>T S3885F	Absent	26,738	99.9	2,840	100.0	29,578	99.9	0.717
	11919C>T S3885F	Present	21	0.1	1	–	22	0.1	0.717
	12073C>T D3936D	Absent	26,750	100.0	2,834	99.8	29,584	99.9	<0.001*
	12073C>T D3936D	Present	9	–	7	0.2	16	0.1	<0.001*
	11962C>T L3899L	Absent	26,746	100.0	2,840	100.0	29,586	100.0	1.000
	11962C>T L3899L	Present	13	–	1	–	14	–	1.000
nsp8	12478G>A M4071I	Absent	26,757	100.0	2,750	96.8	29,507	99.7	<0.001*
	12478G>A M4071I	Present	2	–	91	3.2	93	0.3	<0.001*
	12550G>A L4095L	Absent	26,697	99.8	2,841	100.0	29,538	99.8	–
	12550G>A L4095L	Present	62	0.2	–	–	62	0.2	–
	12415C>T N4050N	Absent	26,725	99.9	2,841	100.0	29,566	99.9	–
	12415C>T N4050N	Present	34	0.1	–	–	34	0.1	–
	12557A>G I4098V	Absent	26,729	99.9	2,841	100.0	29,566	99.9	–
	12557A>G I4098V	Present	30	0.1	–	–	30	0.1	–
	12400C>T L4045L	Absent	26,734	99.9	2,840	100.0	29,574	99.9	0.508
	12400C>T L4045L	Present	25	0.1	1	–	26	0.1	0.508
nsp12	14408C>T P4715L	Absent	7,498	28.0	702	24.7	8,200	27.7	<0.001*
	14408C>T P4715L	Present	19,261	72.0	2,139	75.3	21,400	72.3	<0.001*
	14805C>T Y4847Y	Absent	24,397	91.2	2,704	95.2	27,101	91.6	<0.001*
	14805C>T Y4847Y	Present	2,362	8.8	137	4.8	2,499	8.4	<0.001*
	13730C>T A4489V	Absent	26,238	98.1	2,820	99.3	29,058	98.2	<0.001*
	13730C>T A4489V	Present	521	1.9	21	0.7	542	1.8	<0.001*
	13536C>T Y4424Y	Absent	26,469	98.9	2,823	99.4	29,292	99.0	0.025*
	13536C>T Y4424Y	Present	290	1.1	18	0.6	308	1.0	0.025*
	13862C>T T4533I	Absent	26,535	99.2	2,833	99.7	29,368	99.2	0.001*
	13862C>T T4533I	Present	224	0.8	8	0.3	232	0.8	0.001*
nsp14	18060C>T L5932L	Absent	25,247	94.3	2,768	97.4	28,015	94.6	0.001*
	18060C>T L5932L	Present	1512	5.7	73	2.6	1585	5.4	0.001*
	18877C>T L6205L	Absent	26,185	97.9	2,522	88.8	28,707	97.0	0.001*
	18877C>T L6205L	Present	574	2.1	319	11.2	893	3.0	0.001*
	18998C>T A6245V	Absent	26,454	98.9	2,836	99.8	29,290	99.0	0.001*
	18998C>T A6245V	Present	305	1.1	5	0.2	310	1.0	0.001*
	18736T>C F6158L	Absent	26,751	100.0	2,613	92.0	29,364	99.2	0.001*
	18736T>C F6158L	Present	8	–	228	8.0	236	0.8	0.001*
	19524C>T L6420L	Absent	26,530	99.1	2,825	99.4	29,355	99.2	0.102
	19524C>T L6420L	Present	229	0.9	16	0.6	245	0.8	0.102
	Total		26,759	100.0	2,840	100.0	29,600	100.0

Note:

p-value < 0.05 was statistically significant.