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. 2020 Oct 15;39:218. doi: 10.1186/s13046-020-01730-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — SETDB1 promotes invasion, migration and EMT of glioblastoma cells. a Representative images of matrigel invasion assay revealed that ectopic expression of SETDB1 promoted glioblastoma cells invasion. Scale bar: 100 μm. b Representative images of wound-healing assay indicated that ectopic expression of SETDB1 promoted cell migration in glioblastoma cells. Scale bar: 100 μm. c Western blotting of mesenchymal markers (Slug and Vimentin) and epithelial markers (E-cadherin) in cells transfected with SETDB1 or control plasmid. Scale bar: 100 μm. d Representative images of matrigel invasion assay revealed that downregulation of SETDB1 suppressed glioblastoma cells invasion. Scale bar: 100 μm. e Representative images of wound-healing assay indicated that downregulation of SETDB1 suppressed cell migration in glioblastoma cells. f Western blotting of mesenchymal markers (Slug and Vimentin) and epithelial markers (E-cadherin) in cells transfected with stable shRNA against SETDB1. Results were expressed as means ± SD of 3 independent experiments. **, P < 0.01