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Effect of PFOA on the expression levels of tight junction genes Tjps and Ocln in intestinal tissues of CD1 mice. Mice were treated with control (0.5% Tween-20 in water) or 1–20 mg/kg/day PFOA for 10 days. (A) Change in the mRNA expression of Tjp1, Tjp2, and Ocln genes in the small intestine; (B) change in mRNA expression of Tjp1, Tjp2, and Ocln genes in the colon. Statistical values were considered significant at p-value ≤ 0.05 (denoted by “*”) and less significant at p-value > 0.05.
