Table 1.

Probability rate of substitution (R) using maximum likelihood statistical method

	Substitution rate
	A	T/U	C	G
Juke Cantor Model
A	-	8.33	8.33	8.33
T/U	8.33	-	8.33	8.33
C	8.33	8.33	-	8.33
G	8.33	8.33	8.33	-
Tamura Model
A	-	9.45	6.36	7.4
T/U	9.45	-	7.4	6.36
C	9.45	11	-	6.36
G	11	9.45	6.36	-
Tamura-Nei Model
A	-	9.93	6.1	8.31
T/U	8.78	-	6.79	6.49
C	8.78	11.06	-	6.49
G	11.24	9.93	6.1	-
Kimura-2 Parameter Model
A	-	7.84	7.84	9.32
T/U	7.84	-	9.32	7.84
C	7.84	9.32	-	7.84
G	9.32	7.84	7.84	-
Hasegawa-Kishino-Yano Model
A	-	9.95	6.11	7.74
T/U	8.79	-	7.27	6.5
C	8.79	11.84	-	6.5
G	10.46	9.95	6.11	-
General Time Reversible Model
A	-	12.05	8.25	8.97
T/U	10.64	-	6	3.64
C	11.87	9.78	-	5.72
G	12.13	5.57	5.38	-

Transitional substitutions are shown in bold and transversionsal substitutions are shown in italics.