Table 5.

Overall effect size for CAL gain.

Comparison	Systematic Reviews	Studies Included	Defects (Test/Control)	Effect Size: SMD (95% CI)	Statistical Significance	p-Value
PRP vs. OFD	Panda et al., 2016 [31]	1	18/18 *	0.10 (95% CI: −0.09; 0.29) *	No	0.30 *
PRF vs. OFD	Shah et al., 2014 [25]	5	103/102	0.95 (95% CI: 0.20, 1.71)	Yes	<0.001 *
	Panda et al., 2016 [31]	4	81/80 *	1.48 (95% CI: 1.16, 1.79)	Yes	0.003 *
	Castro et al., 2017 [27]	6	129/129	1.20 (95% CI: 0.5, 1.9)	Yes	<0.001
	Li et al., 2019 [29]	12	287/287	1.29 (95% CI: 0.96–1.61)	Yes	0.00001
PRP + graft vs. graft	Del Fabbro et al., 2011 [23]	6	113/115	0.84 (95% CI: 0.27, 1.42)	Yes	0.004
	Panda et al., 2016 [31]	7	141/140 *	2.00 (95% CI: 1.68, 2.32)	Yes	<0.001 *
	Zhou et al., 2018 [32]	4 **	76/76	0.80 (95% CI: 0.27, 1.32	Yes	NA
	Hou et al., 2016 [24]	8	151/149	1.22 (95% CI: 0.88, 1.57)	Yes	<0.00001
PRP + GTR vs. GTR	Del Fabbro et al., 2011 [23]	4	66/66	0.04 (95% CI: −0.33, 0.41)	No	0.75
	Panda et al., 2016 [31]	4	66/66 *	0.03 (95% CI: −0.32, 0.37)	No	0.74 *
	Hou et al., 2016 [24]	4	66/66	0.08 (95% CI: −0.30, 0.46)	No	0.67
PRF + graft vs. graft	Zhou et al., 2018 * [32]	2	40/40	1.61 (95% CI: 1.10, 2.12)	Yes	NA
APC vs. OFD	Del Fabbro et al., 2018 [22]	12	255/255	1.47 (95% CI 1.11 to 1.82)	Yes	<0.00001
	Baghele et al., 2019 [33]	16	504/501	0.39 (95% CI, 0.35, 0.43)	Yes	<0.00001
APC + graft vs. graft	Del Fabbro et al., 2018 [22]	12	284/284	0.72 (95% CI 0.43 to 1.00)	Yes	<0.00001
APC + GTR vs. GTR	Del Fabbro et al., 2018 [22]	7	124/124	0.42 (95% CI −0.02, 0.86)	No	0.060
APC + EMD vs. EMD	Del Fabbro et al., 2018 [22]	2	38/37	0.10 (95% CI−0.13, 0.32)	No	0.40

PRP = platelet-rich plasma; PRF = platelet-rich fibrin; OFD = open flap debridement; GTR = guided tissue regeneration; NA = not available; SDM = standardized mean difference; CI = confidence interval. * data provided by the authors. ** only DFDBA considered by the authors.