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. 2020 Oct 14;12(1):e12088. doi: 10.1002/dad2.12088

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© 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Sensor schematic. Shown is a schematic of the steps taken in the manufacture of a gas sensor. After removal of the template molecule (volatile organic compound [VOC]) from the molecular imprinting polymer (MIP) layer, there will be cavities with the exact size and shape of the template molecule (eg, pivalic acid) on the MIP surface. Steps in the fabrication process include: (A) deposition of 20 nm chromium on silicon substrate; (B) screen printing of graphene and Prussian blue layer; (C) molecular imprinting of the polymer layer formed through electro‐polymerization of polypyrrole around the template biomarker molecule to be detected; and (D) 50 nm‐thick gold electrode deposition and patterning