The expression of the (A) γH2AX, (B) FOXO3a, (C) IGF-1 and (D) Bim mRNAs in ovaries from 10-week old offspring. The offspring were from the HF/HF, HF/C, C/HF and C/C groups (n=16). The values are presented as the relative fold changes normalized to the C/C group, with 1 representing the value obtained for the C/C group. All values are reported as means ± SEM. *P<0.05 vs. the C/C group; #P<0.05 vs. the HF/C group; ΔP<0.05 vs. the C/HF group (one-way ANOVA). FOXO3a, forkhead box protein O3a; IGF-1, insulin-like growth factor 1; γH2AX, phosphorylated form of H2AX histone variant; Bim, Bcl-2-like protein 11; HF, high fat; C, control.