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. 2020 Apr 19;5(5):880–888. doi: 10.1016/j.adro.2020.03.021

Table 2.

Univariable and multivariable linear regression associating baseline variables with lymphocyte nadirs (109 cells/L) during radiation treatment


Characteristic
Univariable analysis
Multivariable analysis
Regression coefficient 95% CI P Regression coefficient 95% CI P
Male (vs female) 0.048 –0.039 to 0.136 .278 NI
Age (1 y) –0.001 –0.005 to 0.002 .537 NI
Stage
 N3 (vs N2 and N1) –0.085 –0.206 to 0.037 .168 NI
Baseline lymphocyte (109 cells/L) 0.112 0.068-0.156 <.001 0.098 0.060-0.135 <.001
Chemotherapy
 5 courses (vs fewer than 5 courses) 0.060 –0.005 to –0.126 .071 0.044 –0.005 to 0.093 .081
Radiation therapy
 Log PTV –0.393 –0.629 to –0.158 .001 –0.205 –0.399 to –0.011 .038
 EDIC –0.085 –0.115 to –0.055 <.001 –0.061 –0.089 to –0.034 <.001
 IMRT (vs 3DCRT) 0.019 –0.047 to 0.084 .567 NI

Abbreviations: 3DCRT = 3-dimensional conformal radiation therapy; CI = confidence interval; EDIC = effective dose to the circulating immune cells; IMRT = intensity modulated radiation therapy; NI = not included; PTV = planning target volume.