Table 2.

Favored Prebiopsy Clinical Diagnosis^a,b

Diagnosis	Total (N=271)	TBFB (n=151)	TBCB (n=120)	P valuec
Granulomatous, noninfectiousd	133 (49)	76 (50)	57 (48)	.64
Non-IPF fibrotic ILDe	66 (24)	28 (19)	38 (32)	.012
Infectionf	60 (22)	46 (31)	14 (12)	<.001
Organizing pneumoniag	53 (20)	36 (24)	17 (14)	.046
Indeterminate ILDh	52 (19)	31 (21)	21 (18)	.53
IPF/UIPi	33 (12)	10 (7)	23 (19)	.002
Eosinophilic pneumonia	29 (11)	23 (15)	6 (5)	.007
Neoplasmj	27 (10)	14 (9)	13 (11)	.67
Vasculitis	21 (8)	13 (9)	8 (7)	.55
RB-ILD/DIP	19 (7)	10 (7)	9 (8)	.78
Aspirationk	17 (6)	5 (3)	12 (11)	.024
pLCH	4 (2)	3 (2)	1 (0.8)	.43
DAH	6 (2)	4 (3)	2 (2)	.59
Amyloid	3 (1)	1 (0.7)	2 (2)	.43
CHFl	3 (1)	2 (1)	1 (0.8)	.70
Bronchiolitis	3 (1)	2 (1)	1 (0.8)	.70
PAP	3 (1)	2 (1)	1 (0.8)	.70
LAM	1 (0.4)	1 (0.7)	0	.37
Pneumoconiosis	1 (0.4)	1 (0.7)	0	.37

^aCHF = congestive heart failure; DAH = diffuse alveolar hemorrhage; DIP = desquamative interstitial pneumonia; ILD = interstitial lung disease; IPF = idiopathic pulmonary fibrosis; LAM = lymphangioleiomyomatosis; NSIP = nonspecific interstitial pneumonia; PAP = pulmonary alveolar proteinosis; pLCH = pulmonary Langerhans cell histiocytosis; RB-ILD = respiratory bronchiolitis-interstitial lung disease; TBCB = transbronchial cryobiopsy; TBFB = transbronchial forceps biopsy; UIP = usual interstitial pneumonia.

^bData are presented as No. (percentage).

^cChi-square test.

^dNoninfectious granulomatous process, eg, sarcoidosis (well-formed noncaseating granulomas), hypersensitivity pneumonitis (poorly formed granulomas, lymphocytic interstitial infiltrates, and cellular bronchiolitis).

^eNon-IPF fibrotic ILD such as NSIP.

^fInfections presenting as ILD (eg, Cytomegalovirus pneumonia).

^gOrganizing pneumonia, eg, cryptogenic organizing pneumonia, connective tissue disease–associated ILD, and drug-induced lung disease.

^hIndeterminate clinicoradiographic pattern.

ⁱCases in which a radiographic pattern consistent with UIP and clinical diagnosis with IPF.

^jNeoplastic diseases presenting as ILD (eg, lymphangitis carcinomatosis and lymphoproliferative diseases).

^kAspiration (eg, food or vegetable matter with pneumonia).

^lCongestive heart failure presenting as ILD.