Table 3.
Incidence rates and hazard ratios of vancomycin compared to all comparators stratified for antibiotic treatment duration.
N | Cases | Person timeb | Incidence rateb | 95% CI | Crude HR | 95% CI | Adjusted HRc | 95% CI | |
---|---|---|---|---|---|---|---|---|---|
< 7 days of treatment | |||||||||
Vancomycina | 4347 | 8 | 18.25 | 0.44 | 0.22–0.88 | ||||
Comparators | 23,965 | 72 | 100.67 | 0.72 | 0.57–0.90 | 0.61 | 0.30–1.27 | 0.49 | 0.22–1.08 |
7 to 14 days of treatment | |||||||||
Vancomycina | 871 | 9 | 3.64 | 2.47 | 1.28–4.75 | ||||
Comparators | 2845 | 23 | 11.88 | 1,94 | 1.29–2.91 | 1.28 | 0.59–2.76 | 0.89 | 0.37–2.12 |
> 14 days of treatment | |||||||||
Vancomycina | 231 | 5 | 0.96 | 5.19 | 2.16–12.48 | ||||
Comparators | 738 | 12 | 3.08 | 3.89 | 2.21–6.86 | 1.34 | 0.47–3.79 | 0.89 | 0.26–3.10 |
95% CI 95% confidence interval, HR hazard ratio.
aIndex group.
bPer 10 person-years.
cAdjusted for age, gender, medical history, co-medication, type of surgery, main diagnosis;