Fig. 2. Copy number alterations associated with relapse.

a Net change of CNA frequency in primary and matched relapse tumours; red and blue bars represent positive and negative changes respectively. Only significant events with changes in at least two tumours are shown. b Copy number profiles of patients 7842, 9166, and 9515. In 7842 copy number neutral loss of heterozygosity (nLOH) at chromosome 4 becomes LOH at relapse. In 9166 LOH at 13q progresses to complete loss of 13q. In 9515 copy number gain at chromosome 10 and 11 progresses to additional chromosome gain. Thick and thin lines represent clonal and subclonal copy number states, respectively. Yellow and blue lines denote total and minor copy number respectively (copy number states >5 not shown). c Patterns of copy number change across paired primary-relapse samples at 11q and 14q. Lines indicate relationship between primary and matched relapse tumours, with width being proportional to event frequency. Only chromosome arms with copy number alterations (CNAs) are plotted, with a copy number of 2 corresponding to nLOH.