. 2020 Oct 14;10(10):101. doi: 10.1038/s41408-020-00367-2

Table 2.

Summary of relapse-specific coding driver mutations, promoter mutations, CRE mutations, driver translocations, and large-scale genomic changes identified in 24 primary tumour-relapse pairs grouped by subtype.

Subtype	Coding drivers	Promoters	CREs	Driver translocations	Frequent large-scale genomic changes
t(4;14)	KRAS; TP53; FGFR3; FAM46C; TRAF2; NF1; XBP1	MTFRL1; FLT3LG; IL12A; POLG; XBP1; B3GALNT1; ALG10B	ABCA10; ABCA5	MAP3K14 t(17,14)(q21,q32)	17p deletion Further copy number changes at unstable genomic regions (11q and 14q) Increased telomere length
t(11;14)	PRDM1; LTB; IDH2; KRAS; NRAS; CCND1; ATM; FAM154B; MLL3	RBX1; FAM81A; POLG; KCTD13; SCML1	SCAF8
t(14;16)	NRAS; TET2	MYO1E; ALG10B; TMSB4X; KCTD13; SCML1

Subtype

Coding drivers

Promoters

CREs

Driver translocations

Frequent large-scale genomic changes

t(4;14)

KRAS; TP53; FGFR3; FAM46C; TRAF2; NF1; XBP1

MTFRL1; FLT3LG; IL12A; POLG; XBP1; B3GALNT1; ALG10B

ABCA10; ABCA5

MAP3K14 t(17,14)(q21,q32)

17p deletion

Further copy number changes at unstable genomic regions (11q and 14q)

Increased telomere length

t(11;14)

PRDM1; LTB; IDH2; KRAS; NRAS; CCND1; ATM; FAM154B; MLL3

RBX1; FAM81A; POLG; KCTD13; SCML1

SCAF8

t(14;16)

NRAS; TET2

MYO1E; ALG10B; TMSB4X; KCTD13; SCML1

CRE cis-regulatory element.