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. 2020 Oct 14;11:5155. doi: 10.1038/s41467-020-18958-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Strategy for modification of the shikimate pathway and MVA pathway to enhance precursor supply. The genes that are overexpressed are highlighted in green, and those knocked out are shown in gray. PP Pathway pentose phosphate pathway, PEP phosphoenolpyruvate, E4P D-erythrose-4-phosphate, DAHP 7P-2-dehydro-3-deoxy-D-arabino-heptonate, 4-HPP 4-hydroxy-phenylpyruvate, PPY phenylpyruvate, Tyr tyrosine, Phe phenylalanine, MVA pathway mevalonic acid pathway, HMG-CoA 3-hydroxy-3-methyl-glutaryl-CoA, FPP farnesyl pyrophosphate, GGPP geranylgeranyl diphosphate, IAA indole acetaldehyde, PAA phenylacetaldehyde, 4-HPAA 4-hydroxyphenylacetaldehyde, Tkl1 transketolase, Aro4 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, Aro7 chorismate mutase, Tyr1/TyrC cyclohexadienyl dehydrogenase, Aro10 phenylpyruvate decarboxylase, Aro8/Aro9 tyrosine aminotransferase, tHMG1 truncated 3-hydroxy-3-methyl-glutaryl reductase, CrtE geranylgeranyl diphosphate synthase. b Effect of stepwise optimization of shikimate pathway on HGA accumulation in YS-11. YS-11+Tyr indicates YS-11 cultured with exogenously addition of tyrosine. All values presented are the means of three biological replicates, and error bars represent standard deviations. Source data are provided as a Source Data file.