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. 2020 Oct 14;11:5155. doi: 10.1038/s41467-020-18958-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a Time courses of cell growth, tocotrienols production and consumption of carbon sources during temperature-regulated high-density fermentation of tocotrienols by YS-M5GP3(+). The duration of cold shock at 24 °C is from 40 to 45th h. b Composition of tocotrienols produced by the end of YS-M5GP3(+) fermentation. T3 is short for tocotrienol. c Transcription levels of GAL4/GAL4M9, HPPD, SyHPT in YS-M5GP3(+) during fermentation. All values presented are the means of three biological replicates, and error bars represent standard deviations. Source data are provided as a Source Data file.