Table 2.
Important nodes with network analyzer results.
| Name | Betweenness centrality | Closeness centrality | Clustering coefficient | Degree | Topological coefficient |
|---|---|---|---|---|---|
| AKT1 | 0.15105568 | 0.42124542 | 0.23913043 | 24 | 0.16908213 |
| GSK3B | 0.00818 | 0.3422619 | 0.33333333 | 7 | 0.28011204 |
| CDK1 | 0.04618775 | 0.3133515 | 0.42222222 | 10 | 0.25 |
| CCNA2 | 0.05253746 | 0.32951289 | 0.48888889 | 10 | 0.23658537 |
| CSNK2B | 0 | 0.22157996 | 1 | 2 | 0.59090909 |
| CSNK2A1 | 0.01619132 | 0.24364407 | 0.16666667 | 4 | 0.27777778 |
| VEGFA | 0.05497117 | 0.40636042 | 0.31481481 | 28 | 0.18434874 |
| KDR | 0.00489856 | 0.33923304 | 0.55555556 | 10 | 0.34782609 |
| NOS3 | 0.03367264 | 0.38333333 | 0.36363636 | 12 | 0.23870056 |
| AURKB | 0 | 0.26436782 | 1 | 6 | 0.49019608 |
| PLK1 | 0.04334413 | 0.30913978 | 0.47222222 | 9 | 0.2251462 |
| HRAS | 0.09982428 | 0.40069686 | 0.25846154 | 26 | 0.18131868 |
| EGFR | 0.10619747 | 0.40636042 | 0.27272727 | 23 | 0.1970547 |
| TOP2A | 0.03747492 | 0.26995305 | 0.44444444 | 9 | 0.32716049 |
| TOP1 | 0 | 0.21296296 | 0 | 1 | 0 |
| IL5 | 0.00137232 | 0.35060976 | 0.73333333 | 6 | 0.38461538 |
| IL2 | 0.00626375 | 0.36741214 | 0.58333333 | 9 | 0.3132969 |
| CCNA1 | 0.00101686 | 0.3042328 | 0.7 | 5 | 0.39230769 |
| PIK3R1 | 0.1135341 | 0.4020979 | 0.24074074 | 28 | 0.17176871 |
| INSR | 1.72E−04 | 0.3314121 | 0.9 | 5 | 0.47916667 |
| IGF1R | 0.0013309 | 0.33625731 | 0.58333333 | 9 | 0.38164251 |
| NEK2 | 0 | 0.26436782 | 1 | 6 | 0.49019608 |
| CREB1 | 0.05089584 | 0.37337662 | 0.31818182 | 12 | 0.2295082 |
| FLT4 | 1.24E−04 | 0.32122905 | 0.80952381 | 7 | 0.42857143 |
| AGL | 0 | 1 | 0 | 1 | 0 |
| PYGL | 0 | 1 | 0 | 1 | 0 |
| ESR1 | 0.05830291 | 0.39383562 | 0.36263736 | 14 | 0.21978022 |
| CCND1 | 0.10797187 | 0.41071429 | 0.33333333 | 18 | 0.20422535 |
| MMP9 | 0.08713433 | 0.39655172 | 0.375 | 16 | 0.22420635 |
| PLK4 | 0 | 0.26436782 | 1 | 6 | 0.49019608 |
| MAPT | 0.00399207 | 0.30831099 | 0.3 | 5 | 0.30344828 |
| TERT | 0.02200057 | 0.33527697 | 0.52380952 | 7 | 0.35428571 |
| PGF | 0.0063316 | 0.35276074 | 0.5 | 12 | 0.29716981 |
| TPT1 | 0 | 0.23662551 | 0 | 1 | 0 |
| FGF1 | 0.00111343 | 0.33823529 | 0.63636364 | 11 | 0.34042553 |
| FGF2 | 0.07449146 | 0.39383562 | 0.37662338 | 22 | 0.21306818 |
| MMP2 | 0.00467167 | 0.35714286 | 0.57777778 | 10 | 0.29423077 |
| MET | 6.53E−04 | 0.34124629 | 0.77777778 | 9 | 0.4 |
| SMAD3 | 0.00199754 | 0.33625731 | 0.46666667 | 6 | 0.34848485 |
| ALOX5 | 6.10E−05 | 0.21821632 | 0.9047619 | 7 | 0.77777778 |
| PTGS1 | 0.09914773 | 0.26932084 | 0.67857143 | 8 | 0.50961538 |
| FLT3 | 0.00238706 | 0.33045977 | 0.66666667 | 7 | 0.41883117 |
| TEK | 3.95E−04 | 0.33045977 | 0.71428571 | 7 | 0.44480519 |
| ESR2 | 0.11758808 | 0.37828947 | 0.47619048 | 7 | 0.30295567 |
| LYN | 0.03300857 | 0.36741214 | 0.45454545 | 11 | 0.24633431 |
| SYK | 0.00326702 | 0.33045977 | 0.61904762 | 7 | 0.35191638 |
| HSD17B1 | 0 | 0.23760331 | 1 | 3 | 0.66666667 |
| HSD17B2 | 0 | 0.23760331 | 1 | 3 | 0.66666667 |
| B4GALT1 | 0.5 | 0.8 | 0.33333333 | 3 | 0.55555556 |
| ST3GAL3 | 0 | 0.66666667 | 1 | 2 | 0.75 |
| FGR | 0.01597583 | 0.34638554 | 0.46428571 | 8 | 0.25510204 |
| ST6GAL1 | 0 | 0.5 | 0 | 1 | 0 |
| PTK2 | 0.0039192 | 0.34534535 | 0.51515152 | 12 | 0.30065359 |
| MMP3 | 3.67E−04 | 0.33823529 | 0.86666667 | 6 | 0.37037037 |
| MPG | 0.02074822 | 0.29187817 | 0 | 2 | 0.5 |
| APEX1 | 0.02021823 | 0.24678112 | 0 | 4 | 0.25 |
| IL6 | 0.21357151 | 0.42279412 | 0.22134387 | 23 | 0.16205534 |
| ALOX15 | 0.00360723 | 0.22373541 | 0.75 | 8 | 0.60227273 |
| ALOX12 | 6.10E−05 | 0.21821632 | 0.9047619 | 7 | 0.77777778 |
| ARG1 | 0.03662179 | 0.32951289 | 0.4 | 6 | 0.27222222 |
| POLI | 0.0173913 | 0.22373541 | 0 | 2 | 0.5 |
| POLH | 0 | 0.18312102 | 0 | 1 | 0 |
| MAP3K8 | 0 | 0.29715762 | 0 | 1 | 0 |
| CYP1B1 | 0.11543811 | 0.30263158 | 0.3 | 5 | 0.28571429 |
| GUSB | 0.04549909 | 0.27058824 | 0.5 | 4 | 0.45 |
| MPO | 0.13589779 | 0.33823529 | 0.4 | 6 | 0.27027027 |
| ALOX15B | 0 | 0.21780303 | 1 | 6 | 0.83333333 |
| AXL | 0 | 0.29262087 | 1 | 2 | 0.65517241 |
| ABCC1 | 0 | 0.23046092 | 0 | 1 | 0 |
| ABCG2 | 0.0173913 | 0.2987013 | 0 | 2 | 0.5 |
| ESRRA | 0 | 0.28822055 | 1 | 2 | 0.72222222 |
| SNCA | 0.02432927 | 0.29113924 | 0.23809524 | 7 | 0.28571429 |
| CXCR1 | 0.0825549 | 0.33527697 | 0.30555556 | 9 | 0.21604938 |
| CAMK2B | 0.00167032 | 0.32122905 | 0.16666667 | 4 | 0.35810811 |
| F2 | 0.00591872 | 0.35493827 | 0.3 | 5 | 0.35686275 |
| ALDH1B1 | 0.01815372 | 0.20282187 | 0.16666667 | 4 | 0.42857143 |
| AKR1A1 | 0.03250421 | 0.22373541 | 0 | 3 | 0.38888889 |
| CYP2C9 | 0.00360723 | 0.22373541 | 0.75 | 8 | 0.60227273 |
| CYP1A2 | 0.03517144 | 0.24416136 | 0.3 | 5 | 0.45 |
| AKR1B1 | 0.00833383 | 0.18341308 | 0.2 | 5 | 0.4 |
| QDPR | 0.02290496 | 0.20390071 | 0.33333333 | 3 | 0.45833333 |
| AVPR2 | 0.0173913 | 0.29113924 | 0 | 2 | 0.5 |
| CYP2C8 | 0.00280828 | 0.22330097 | 0.80952381 | 7 | 0.63636364 |
| PIM1 | 0 | 0.28822055 | 1 | 2 | 0.61111111 |
| EPHB4 | 3.05E−04 | 0.32303371 | 0.33333333 | 3 | 0.47747748 |
| OPRD1 | 0 | 0.27251185 | 1 | 5 | 0.50769231 |
| DRD4 | 0.0465845 | 0.27777778 | 0.66666667 | 6 | 0.4047619 |
| PARG | 0 | 0.19827586 | 0 | 1 | 0 |
| P4HB | 0 | 0.29792746 | 0 | 1 | 0 |
| MAOA | 0.03380981 | 0.22637795 | 0 | 3 | 0.375 |
| ADORA1 | 0.00744264 | 0.27380952 | 0.66666667 | 6 | 0.42307692 |
| TTR | 0.00942748 | 0.31944444 | 0.83333333 | 4 | 0.36111111 |
| MMP13 | 4.88E−05 | 0.32485876 | 0.93333333 | 6 | 0.42682927 |
| KLK2 | 0.00705145 | 0.29262087 | 0 | 2 | 0.5 |
| FUT4 | 0.5 | 0.8 | 0.33333333 | 3 | 0.55555556 |
| PKN1 | 0.00167811 | 0.25054466 | 0 | 2 | 0.5 |
| NMUR2 | 0.04100187 | 0.32303371 | 0.52380952 | 7 | 0.2406015 |
| AKR1B10 | 0.00183066 | 0.18282989 | 0.66666667 | 3 | 0.5 |
| HSD17B8 | 0.03606286 | 0.24159664 | 0.5 | 4 | 0.46428571 |
| POLD3 | 0.00607311 | 0.25842697 | 0 | 2 | 0.5 |
| XDH | 0 | 0.1965812 | 0 | 1 | 0 |
| CCR4 | 0 | 0.27251185 | 1 | 5 | 0.50769231 |
| ALPL | 0 | 1 | 0 | 1 | 0 |
| ALPI | 0 | 1 | 0 | 1 | 0 |
| NEU1 | 0 | 0.24838013 | 0 | 1 | 0 |
| IAPP | 0 | 0.2259332 | 0 | 1 | 0 |
| DYRK1A | 0.001214 | 0.28255528 | 0.33333333 | 3 | 0.45098039 |
| ELAVL1 | 0.00120149 | 0.31944444 | 0.66666667 | 4 | 0.39102564 |
| ALK | 0 | 0.31081081 | 1 | 2 | 0.77142857 |
| PLA2G1B | 0 | 0.2173913 | 1 | 5 | 0.84444444 |
| GLO1 | 0.00350393 | 0.19166667 | 0 | 2 | 0.6 |
| ARPP19 | 0 | 0.23908524 | 0 | 1 | 0 |
| FUT7 | 0 | 0.5 | 0 | 1 | 0 |
| NOX4 | 7.19E−05 | 0.30503979 | 0.66666667 | 3 | 0.51851852 |
| BACE1 | 0.0344775 | 0.28606965 | 0 | 2 | 0.5 |
| GRK6 | 0 | 0.25164114 | 0 | 1 | 0 |
| CBR1 | 0.0027995 | 0.18821604 | 0 | 2 | 0.6 |
| FASN | 0 | 0.29715762 | 0 | 1 | 0 |
| ADORA2A | 0.01137633 | 0.2804878 | 0 | 2 | 0.5 |
| NT5E | 0.00173277 | 0.23279352 | 0 | 2 | 0.5 |
| ABCB1 | 0 | 0.28967254 | 0 | 1 | 0 |
| CA9 | 0 | 0.30585106 | 1 | 2 | 0.70833333 |
| SLC5A1 | 0 | 0.28967254 | 0 | 1 | 0 |
| HSPA1A | 0 | 0.29792746 | 0 | 1 | 0 |
| PON1 | 0 | 0.29792746 | 0 | 1 | 0 |