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. 2020 Oct 14;10:17240. doi: 10.1038/s41598-020-73974-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Experimental design; (b) Mean arterial blood pressure (MAP) during hemorrhagic shock procedure (Initial = basal MAP before blood withdrawal, Shock = mean MAP during the 2 h of shock, and Resuscitation = mean MAP during infusion of blood and Ringer Lactate); (c) survival curve during and after hemorrhagic shock. Sham: non-shocked mice; Ov: ovariectomized mice (n = 19); Ov + cE2: ovariectomized mice with chronic estradiol substitution (n = 16); Intact + V: Non ovariectomized mice receiving vehicle (n = 24); Intact + aE2: intact mice receiving 25 µg of estradiol at the end of resuscitation (n = 20). For MAP, no significant difference between groups for each period, P < 0.001 between initial and shock and between shock and resuscitation for all groups. For mortality, there was no significant difference between shocked groups.